Friday, September 08, 2006

Bee Venom Induces Death in Tumour Cells

Bee Venom Secretory Phospholipase A2 and Phosphatidylinositol-Homologues Cooperatively Disrupt Membrane Integrity, Abrogate Signal Transduction and Inhibit Proliferation of Renal Cancer Cells
Cancer Immunol Immunother, 2006 Sep 1

Bee venom secretory phospholipase A2 (bv-sPLA2) and phosphatidylinositol-(3,4)-bisphosphate (PtdIns(3,4)P2) act synergistically to induce cell death in tumour cells of various origins with concomitant stimulation of the immune system. Here, we investigated the mechanisms involved in such actions and examined structural requirements of PtdIns-homologues to inhibit tumour cells in combination with bv-sPLA2…

In conclusion, we suggest that the cytotoxic activity mediated by PtdIns(3,4)P2 and bv-sPLA2 is due to cell death that results from disruption of membrane integrity, abrogation of signal transduction and the generation of cytotoxic lyso-PtdIns(3,4)P2.

2 comments:

PROGRESS said...

Astonished data,however I have many questions
1-Whether be used in this study bee venom directly from bee sting or already prepared bee venom?
2-Is this valid for different types of tumours e.g metastatic breast cancer?

Anonymous said...

I wish to have details of a process of purification of bee venom at a lab level.What we collect is on a electro plate which gets oxidised and brown.